Super Bowl 58 odds, spread, line: Chiefs vs. 49ers picks, predictions, bets by NFL insider on 52-27 run

Jason La Canfora has revealed his Kansas City Chiefs vs. San Francisco 49ers prediction for Super Bowl LVIII

Coach Andy Reid can join elite company when the Kansas City Chiefs square off against the San Francisco 49ers in Super Bowl 58 on Sunday, February 11 at Allegiant Stadium in Las Vegas. The 65-year-old Reid already has won two Super Bowl titles, both with the Chiefs. With a victory over the 49ers, he would become just the fifth head coach to win at least three Super Bowls, joining Bill Belichick (six), Chuck Noll (four), Bill Walsh (three) and Joe Gibbs (three). Reid will match wits against San Francisco's Kyle Shanahan, who is looking to win his first Super Bowl.

The Super Bowl start time is set for 6:30 p.m. ET on CBS and Paramount+. San Francisco is a 2-point favorite in the latest 49ers vs. Chiefs odds, while the over/under for total points scored is 47.5. Before you make any Chiefs vs. 49ers picks or Super Bowl predictions of your own, you need to see what proven NFL expert Jason La Canfora has to say, considering he's entering the 2024 Super Bowl on a red-hot streak.

An NFL insider, La Canfora has covered the league for more than two decades for CBS Sports, The Washington Post and the NFL Network, among other outlets, and this season he became a regular contributor to SportsLine. He enters Super Bowl LVIII on a red-hot roll. La Canfora is 52-27 (+2202) on his last 79 NFL picks.

Now, La Canfora has locked in on 49ers vs. Chiefs from every angle and just locked in his picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and betting lines for Chiefs vs. 49ers: 

• 49ers vs. Chiefs spread: San Francisco -2
• 49ers vs. Chiefs over/under: 47.5 points
• 49ers vs. Chiefs money line: San Francisco -129, Kansas City +109
• SF: RB Christian McCaffrey led the league in rushing (1,459 yards)
• KC: Chiefs ranked second in total defense (289.8 yards per game)
• 49ers vs. Chiefs picks: See picks at SportsLine 
• 49ers vs. Chiefs live stream: Paramount+ (try for free)

Why the 49ers can cover

San Francisco is difficult to beat at full strength. Over the last two seasons, when Brock Purdy, Christian McCaffrey and Deebo Samuel all play the entire game, the 49ers are 15-1, including the playoffs, and outscoring opponents by 15.7 points per game. By contrast, in all other games since Purdy's first start, they are 6-5.

In addition, the 49ers have a pass-rushing menace in Nick Bosa. The 26-year-old defensive end ranked second in the league this season in quarterback hits (35) and third in pressures (95). He also owns the most playoff sacks (10.0) in 49ers history. See which team to back here.

Why the Chiefs can cover

Defensive tackle Chris Jones is a force up front for Kansas City. The 6-foot-6, 310-pound Jones ranked second among all defensive tackles in the NFL this season in sacks (10.5), quarterback hits (33) and pressures (75). For his efforts this season Jones was named a first team All-Pro for the second straight year.

In addition, Chiefs running back Isiah Pacheco enters the game on a roll. The second-year running back out of Rutgers has scored a touchdown in seven straight games (and has eight touchdowns overall during that stretch) dating to the regular season. That's the longest active streak in the league. See which team to pick here.

How to make 49ers vs. Chiefs picks

La Canfora has analyzed Chiefs vs. 49ers and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

Who wins Super Bowl 58, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Chiefs vs. 49ers spread hits hard, all from the expert who is 52-27 on his last 79 NFL picks, and find out.