First tests of oral anthrax vaccine are successful in white-tailed deer

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Researchers at the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) are closer to developing an oral vaccine for anthrax, thanks to a recent study showing an immune response in white-tailed deer.

The paper is published in the Journal of Zoo and Wildlife Medicine.

Having an oral vaccine is crucial for combating anthrax infections in wild animals because the alternative—capturing every single animal and administering an injection vaccine—is practically impossible.

"All mammals are susceptible to anthrax to some degree or another," said Dr. Walt Cook, a clinical professor in the VMBS Department of Veterinary Pathobiology (VTPB). "Ranchers who live in areas that are prone to having anthrax are able to give vaccinations to their herds as part of their routine preventative medical care, but that's impossible to do with wild animals."

Inoculating wild deer populations against anthrax is important because they contribute to outbreaks of this deadly bacteria.

"When an animal infected with anthrax dies, exposure to oxygen causes the anthrax bacteria to release spores as the carcass decomposes," Cook said.

The anthrax spores can then infect another animal that breathes in bits of soil, eats contaminated plants, or drinks contaminated water.

"In the right conditions, those spores can remain active in the soil for decades or even hundreds of years," Cook said. "Once it's in the soil, it's very difficult to remove, so controlling anthrax spore formation is essential."

The ultimate aim of the project is to create an oral vaccine that can be placed in food baits in areas where anthrax is a problem, like the Edwards Plateau in Central Texas. In 2019, the region saw a spike in anthrax-related deaths that may have claimed the lives of up to 10,000 animals in just a few months.

"Anthrax is almost always fatal," Cook said. "Having a vaccine tailor-made for wildlife will be a big step toward containing the spread of the bacteria."

Making an oral vaccine

Turning a vaccine meant to be administered through the skin into an oral treatment isn't a simple process.

The problem is that anthrax spores don't last long enough in the gastrointestinal tract to create an immune response without help, according to Dr. Jamie Benn Felix, an assistant professor at Texas A&M University-Kingsville's Caesar Kleberg Wildlife Research Institute.

As a postdoctoral research associate at Texas A&M University's Cook Wildlife Lab, Benn Felix was able to create a new formula for the oral vaccine using microencapsulation, which uses a protective membrane to slowly release bacteria at a rate that will generate an immune response.

Her work was made possible through the discoveries of another team member, VTPB professor Dr. Allison Rice-Ficht, who developed the encapsulation technique that protects the brucellosis vaccine from stomach acid.

"Thanks to our team's hard work, we were finally able to test the new oral vaccine and our results show that it successfully generated an immune response. That means the encapsulation technique works," Cook said.

The next step for the researchers is testing the best way to administer the vaccine to wild animals through food baits.

More information: Jamie S. Benn et al, LETHAL TOXIN NEUTRALIZING ANTIBODY RESPONSE INDUCED FOLLOWING ORAL VACCINATION WITH A MICROENCAPSULATED BACILLUS ANTHRACIS STERNE STRAIN 34F2 VACCINE PROOF-OF-CONCEPT STUDY IN WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS), Journal of Zoo and Wildlife Medicine (2024). DOI: 10.1638/2023-0065

Provided by Texas A&M University